biomedicines

Biomedicines 2022, 10, 3282.

SCIE

[논문]Bioengineered Ciprofloxacin-Loaded Chitosan Nanoparticles for the Treatment of Bovine Mastitis

Preeti Yadav, Young-Ok Son

프리티 야다브, 손영옥

Awadh Bihari Yadav, Preksha Gaur, Vartika Mishra, Zul-I Huma , Neelesh Sharma

Abstract: Mastitis is the most devastating economic disease in dairy cattle. Mastitis in dairy cattle
frequently occurs during the dry period or during early lactation. Escherichia coli (E. coli) and
Staphylococcus aureus (S. aureus)are the main causative agents of mastitis in India. S. aureus can form
microabscesses in the udder and develop a subclinical form of mastitis. This bacterial property
hinders an effective cure during the lactation period. Antimicrobials used for treatments have a
short half-life at the site of action because of frequent milking; thereforethey are unable to maintain
the desired drug concentration for effective clearance of bacteria. We demonstrated the potential of
ciprofloxacin-encapsulated nanocarriersthat can improve the availability of drugs and provide an
effective means for mastitis treatment. These drug-loaded nanoparticles show low toxicity and slow
clearance from the site of action. Antimicrobial activity against clinical strains of E. coli and S. aureus
showed that the zone of inhibition depended on the dose (0.5 mg to 2 mg/mL nanoparticle solution
from 11.6 to 14.5 mm and 15 to 18 mm). These nanoparticles showed good antimicrobial activity in
broth culture and agar diffusion assay against bacteria.

2022-12-19

https://doi.org/10.3390/biomedicines10123282