[논문] High-Sucrose Diet Accelerates Arthritis Progression in a Collagen-Induced Rheumatoid Arthritis Model

MOLECULAR NUTRITION & FOOD RESEARCH

5.2

1613-4125

Volume 67, Issue 20

SCIE

Scope: High dietary sugar and sweeteners are suspected to cause the
development of rheumatoid arthritis (RA) symptoms through the induction of
proinflammatory cytokine release. However, the mechanisms by which
increased dietary sugar affects RA etiology are not yet fully understood. The
study uses a mouse model of collagen-induced RA (CIA) to investigate the
relationship between excessive sugar consumption and RA risk.
Methods and results: RA-associated pathological features are assessed in the
nonimmunized (NI) control group, the CIA-positive control group, and the
CIA + high-sucrose diet (CIA+HS, 63% calories from sucrose) group.
Compared with the CIA group, the CIA+HS group shows a greater increase in
paw thickness and clinical scores, as well as, a higher degree of pannus
formation and inflammation in the knee, ankle, and sole tissues. Moreover,
the infiltration of immune cells is increased in the CIA+HS group. Although
the expression of hepatic lipogenic genes, is not altered, that of toll-like
receptor (TLR4) and IL-1𝜷 is considerably elevated in the CIA+HS group.
Conclusions: These findings suggest that excessive sucrose consumption
causes hepatic fibrosis and inflammation, contributing to the pathophysiology
of RA.

Yunhui Min, Yunji Heo

Dahye Kim, Mangeun Kim, Jiwon Yang, Hyo Jin Kim, Youngheun Jee, Mrinmoy Ghosh, Inhae Kang,* and Young-Ok Son*

2023-09-08

https://doi.org/10.1002/mnfr.202300244