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[논문] Design and Synthesis of Small Molecules as Potent Staphylococcus aureus Sortase A Inhibitors

Antibiotics

4.639

2079-6382

9(10)

SCIE

The widespread and uncontrollable emergence of antibiotic-resistant bacteria, especially methicillin-resistant Staphylococcus aureus, has promoted a wave of efforts to discover a new generation of antibiotics that prevent or treat bacterial infections neither as bactericides nor bacteriostats. Due to its crucial role in virulence and its nonessentiality in bacterial survival, sortase A has been considered as a great target for new antibiotics. Sortase A inhibitors have emerged as promising alternative antivirulence agents against bacteria. Herein, the structural and preparative aspects of some small synthetic organic compounds that block the pathogenic action of sortase A have been described.

Min Woo Ha, Sung Wook Yi and Seung-Mann Paek,*

2020.10.16.

https://doi.org/10.3390/antibiotics9100706