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[논문] Functional NK Cell Activation by Ovalbumin Immunization with a Monophosphoryl Lipid A and Poly I:C Combination Adjuvant Promoted Dendritic Cell Maturation

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논문제목(Title)

[논문] Functional NK Cell Activation by Ovalbumin Immunization with a Monophosphoryl Lipid A and Poly I:C Combination Adjuvant Promoted Dendritic Cell Maturation

학술지명(Journal)

Vaccines

ImpactFactor

4.422

ISSN_ISBN

EISSN: 2076-393X

학술지볼륨권호(Volume)

9

SCI구분

SCIE

초록(Abstract)

Natural killer (NK) cells are one of the types of innate immune cells to remove pathogen-infected cells and modulate inflammatory immune responses. Recent studies have revealed that NK cells could enhance vaccine efficacy by coordinating the innate and adaptive immune responses. In this study, we have evaluated the efficacy of intranasal ovalbumin (OVA) immunization with a monophosphoryl lipid A (MPL) and polyriboinosinic polyribocytidylic acid (poly I:C) combination adjuvant in promoting NK cell recruitment, differentiation, and activation. The frequencies of NK cells were positively correlated with those of dendritic cells (DCs) at the site of immunization. Moreover, the activated NK cells and DCs by the MPL + poly I:C combination adjuvant induced activations of each other cells in vitro. Taken together, this study suggested that the MPL and poly I:C combination adjuvant in OVA vaccination mediated NK cell activation and cellular crosstalk between NK cells and DCs, suggesting a promising vaccine adjuvant candidate for promoting cellular immune responses.

저자명(Author)

Le, Chau Thuy Tien; Ahn, So Yeon; Kang, Sang-Moo; Ko, Eun-Ju;

학술지출판일자(PublicationDate)

2021.09.23.

공개 및 라이선스

공개 일자

2024-09-03

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컬렉션
[고은주] 면역증강물질 평가와 면역학 및 분자생물학적 기전 연구(2019-2021)
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2024-09-03
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  • Version 1 2024-08-26
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Le, Chau Thuy Tien; Ahn, So Yeon; Kang, Sang-Moo; Ko, Eun-Ju;, 2021.09.23., [논문] Functional NK Cell Activation by Ovalbumin Immunization with a Monophosphoryl Lipid A and Poly I:C Combination Adjuvant Promoted Dendritic Cell Maturation
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