고은주 [논문] Adjuvant effects of combination monophosphoryl lipid A and poly I:C on antigen-specific immune responses and protective efficacy of influenza vaccines Scientific Reports 4.6 2045-2322 13 SCIE Toll-like receptor (TLR) agonists improve vaccine immunogenicity and efficacy, but they are currently unlicensed as adjuvants in influenza vaccines. This study aimed to investigate whether a combination of monophosphoryl lipid A (MPL, a TLR4 agonist) and polyriboinosinic polyribocytidylic acid (poly I:C, a TLR3 agonist) can enhance the protective efficacy of an inactivated A/Puerto Rico/8/1934 (A/PR8) H1N1 influenza vaccine against homologous influenza infection and minimize illness outcomes. Results showed that combination MPL and poly I:C adjuvanted influenza vaccination increased the production of antigen-specific antibodies, decreased the levels of cytokines and cellular infiltrates at the infection sites, and induced significant memory T and B cell responses in mice. The results of this study suggest that the combination of MPL and poly I:C can be developed into a possible adjuvant for enhancing the efficacy of influenza vaccines. Chau Thuy Tien Le, So Yeon Ahn, Thi Len Ho, Jueun Lee, Dong-Ha Lee, Hye Suk Hwang, Sang-Moo Kang & Eun-Ju Ko 2023.07.28 https://doi.org/10.1038/s41598-023-39210-6 CC BY-NC 이 데이터의 저작권은 <연구자 기관/그룹/사용자>에게 있습니다.