Pharmaceuticals

EISSN: 1424-8247

2022, 15, 387

SCIE

[논문]Daphne jejudoensis Attenuates LPS-Induced Inflammation by Inhibiting TNF-α, IL-1β, IL-6, iNOS, and COX-2 Expression in PeriodontalLigamentCells

Ji-Yeong Bae

배지영

Dong-Seol Lee, You Kyoung Cho, Ji-Yeon Lee, Joo-Hwang Park and Sang Ho Lee

Periodontitis is a common disease involving inflammation and tissue destruction in the
periodontal region. Although uncontrolled long-term inflammation in the gingiva may lead to loss of
the periodontal ligament, treatments or preventive solutions for periodontitis are scarce. The aim
of this study is to find anti-inflammatory material from a natural source that can be used to treat or
protect against periodontitis. Daphne species (Thymelaeaceae) are important and popular components
of traditional Chinese medicine and are used as anti-inflammatory agents. Daphne jejudoensis is an en￾demic plant that grows on Jeju Island and was identified as a new species in 2013. In this study, for the
first time, we investigated the anti-inflammatory effect of D. jejudoensis leaf extract (DJLE) on human
periodontal ligament cells. The gene expression levels of pro-inflammatory cytokines (interleukin-1β
and 6 and tumor necrosis factor-α) and inflammation-inducible enzymes (inducible nitric oxide
synthase and cyclooxygenase-2) were reduced after DJLE treatment with/without lipopolysaccha￾ride stimulation. The findings of this study indicate that D. jejudoensis possesses anti-inflammatory
activities, suggesting that DJLE may be a potential preventive and therapeutic agent for periodontitis.
Key

2022.03.22.

https://doi.org/10.3390/ph15040387